胡连瑞

个人简介

胡连瑞,博士,讲师,男,西华大学青年学者后备人才。2010年获西华大学应用化学专业本科学位,2011-2012年分别就职于康龙化成(北京)新药技术有限公司、上海睿智化学研究有限公司,任助理研究员。2017年获中国科学院化学研究所物理化学专业博士学位,2017年毕业任职于西华大学理学院,2019年赴德国哥廷根大学开展博士后研究。 主要从事理论与计算化学等方面的科研工作。围绕高精度从头算波函数方法,3d过渡金属催化有机反应机理研究,生物酶反应机理等方面的研究已发表相关论文17篇,其中JCR一区论文7篇,包括J. Am. Chem. Soc.(5篇),Acs Catal.(1篇), J. Chem. Theory Comput.(3篇),J. Phys. Chem. Lett.(1篇), Chem. Eur. J.(2篇)等SCI收录论文。先后受邀参加多次国际国内学术研讨会,作为项目负责人承担国家教育部、四川省科技厅面上项目等多个纵向项目的研究工作。

工作经历

2010~2011 康龙化成(北京)新药技术有限公司 助理研究员 2011~2012 上海睿智化学研究有限公司 助理研究员

教育经历

2012.09~2017.07 中国科学院化学研究所 物理化学专业(硕博连读) 博士 2006.09~2010.06 西华大学 应用化学专业 学士

研究方向

1.过渡金属催化的有机反应机理(主要是3d过渡金属)

2.高精度理论计算研究

3.分子结构和分子光谱的理论模拟

4.生物酶反应机理

学术成果

1.Hu, L. R.; Chen, H.* Substrate-Dependent Two-State Reactivity in Iron-Catalyzed Alkene [2+2] Cycloaddition Reactions J. Am. Chem. Soc.2017, 139, 15564-15567.

2.Hu, L. R.; Chen, H.* What Factors Control the Reactivity of Cobalt-Imido Complexes in C-H Bond Activation via Hydrogen Abstraction? Acs Catal.20177, 285.

3.Hu, L. R.; Chen, K.; Chen, H.* Modeling σ-Bond Activations by Nickel(0) Beyond Common Approximations: How Accurately Can We Describe Closed-Shell Oxidative Addition Reactions Mediated by Low-Valent Late 3d Transition Metal? J. Chem. Theory Comput.201713, 4841-4853. (L.H. and K.C. contributed equally.)

4.Hu, L. R.; Chen, H.* Assessment of DFT Methods for Computing Activation Energies of W/Mo-Mediated Reactions J. Chem. Theory Comput.201511, 4601.

5.Hu, L. R.; Chen, H.* Comparative thereotical study on C-C/C-N/C-Br Bond Formations in RhIII-catalyzed C-H bond functionalizations: stepwise versus concerted mechanisms J. Organomet. Chem.2018864, 105-109.

6.Wang, L.; Hu, L. R.; Zhang, H. Z.; Chen, H.*; Deng, L.* Three-Coordinate Iron(IV) Bisimido Complexes with Aminocarbene Ligation: Synthesis, Structure and Reactivity J. Am. Chem. Soc.2015137, 14196-14207. (L.W. and L.H. contributed equally.)

7.Liu, J.; Hu, L. R.; Wang, L.; Chen, H.*; Deng, L.* An Iron(II) Ylide Complex as A Masked Open-Shell Iron Alkylidene Species in Its Alkylidene-Transfer Reactions with Alkenes J. Am. Chem. Soc.2017, 139, 3876-3888. (L.J. and L.H. contributed equally.)

8.Wang, C.; Zhao, C. Y.; Hu, L. R.;Chen, H.*Evidences toward Establishing Mechanism of Cyanobacterial Aldehyde-Deformylating Oxygenase: Asymmetric Aldehyde Activation by Symmetric Diiron CofactorJ. Phys. Chem. Lett., 2016, 7, 4427–4432.

9.Kumar, P.; Lee, Y. M.; Hu, L. R.; Chen, J.; Park, Y. J.; Yao, J.; Chen, H.*; Karlin, K. D.*; Nam, W.* Factors That Control the Reactivity of Cobalt(III)-Nitrosyl Complexes in Nitric Oxide Transfer and Dioxygenation Reactions: A Combined Experimental and Theoretical InvestigationJ. Am. Chem. Soc.2016138, 7753-7762.

10.Lu, S. J.; Hu, L. R.; Xu, X. L.; Xu, H. G.; Chen, H.*; Zheng, W.*Transition from exohedral to endohedral structures of AuGen (n = 2–12) clusters: photoelectron spectroscopy and ab initio calculationsPhys. Chem. Chem. Phys.201618, 20321-20329.

11.Sun, Y.; Tang, H.; Chen, K.;Hu, L. R.; Yao, J.; Shaik, S.; Chen, H.* Two-State Reactivity in Low-Valent Iron-Mediated CH Activation and the Implications for Other First-Row Transition Metals J. Am. Chem. Soc.2016138, 3715-3730.

12.Liu, Q.-Y.; Hu, L. R.; Chen, H.*; He, S.-G.* Photoelectron Imaging Spectroscopy of ZrO Diatomic Anion Chinese J. Chem. Phys.201528, 452.

13.Li, Z.-Y.; Hu, L. R.; Liu, Q.-Y.; Ning, C.-G.; Chen, H.*; He, S.-G.*; Yao, J. N. Thermal CH Bond Activation by MoC3 Cluster Anions: Carbon Stabilizes Low-Spin States for Oxidative Addition Chem. Eur. J.201521, 17748-17756.

14.Liu, Q.-Y.; Hu, L. R.; Li, Z.-Y.; Ning, C.-G.; Ma, J.-B.; Chen, H.*; He, S.-G.* Photoelectron Imaging Spectroscopy of MoC and NbN Diatomic Anions: A Comparative Study J. Chem. Phys.2015142, 164301.

15.Sun, Y. Y.; Hu, L. R.; Chen, H.* Comparative Assessment of DFT Performances in Ru- and Rh-Promoted σ-Bond Activations J. Chem. Theory Comput.201511, 1428.

16.Liu, Y. B.; Hu, L. R.; Chen, H.*; Du, H. F.* An Alkene-Promoted Borane-Catalyzed Highly Stereoselective Hydrogenation of Alkynes to Z- and E-Alkenes Chem. Eur. J.201521, 3495.

17.Lei, Y.; Wang, L; Hu, L. R.; Shen, X. H.* An approximate approach for the electronic vibration of Al2O3X2 (X = H, D, T) Acta. Phys. Sin.201261, 232501.

教学工作

荣誉奖励

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